4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

Base Information

Chemical Name:4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol
CAS No.:1437311-46-0
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

Synonyms:4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

Suppliers and Price of 4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

There total 2 articles about 4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4039-82-1
Benzyl propargyl ether

: 126680-71-5
2-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde

: 1437311-46-0
4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

Guidance literature:: Benzyl propargyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

2-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde; In tetrahydrofuran; hexane; at 20 ℃; for 1h;
DOI:10.1021/ol4011129

Reference yield:

: 81168-17-4
2-(tert-butyldimethylsiloxymethyl)benzyl alcohol

: 1437311-46-0
4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 1 h / 20 °C

With n-butyllithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; ethyl acetate;
DOI:10.1021/ol4011129

Reference yield: 90.0%

: 1437311-46-0
4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol

: 106-95-6
allyl bromide

: 1437311-47-1
((2-(1-(allyloxy)-4-(benzyloxy)but-2-yn-1-yl)benzyl)oxy)(tert-butyl)dimethylsilane

Guidance literature:: 4-(benzyloxy)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)but-2-yn-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.666667h;

allyl bromide; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;
DOI:10.1021/ol4011129