3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

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Chemical Name:3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline
CAS No.:1353575-84-4
Molecular Formula:C₁₈H₁₈ClFN₄S₂
Molecular Weight:408.951
Hs Code.:

Synonyms:3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

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Chemical Property of 3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

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Technology Process of 3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

There total 6 articles about 3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1353575-85-5
N-(3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)pivalamide

: 1353575-84-4
3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

Guidance literature:: N-(3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)pivalamide; With hydrogenchloride; In ethanol; water; at 80 ℃; for 18h;

With sodium hydrogencarbonate; In ethanol; water; pH=8;

Reference yield:

: 179897-90-6
1,3-dibromo-2-chloro-5-fluoro-benzene

: 1353575-84-4
3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

2.1: triethylamine / [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride / 18 h / 100 °C / 3620.13 Torr / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

3.2: 1 h / 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 1 h / -5 - 5 °C

5.1: ISOPROPYLAMIDE / 4 h / 20 - 80 °C / Inert atmosphere

6.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

6.2: pH 8

With hydrogenchloride; N-Bromosuccinimide; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 1353575-26-4
N-(3-bromo-2-chloro-5-fluorphenyl)pivalamide

: 1353575-84-4
3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluoroaniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride / 18 h / 100 °C / 3620.13 Torr / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / -5 - 5 °C

4.1: ISOPROPYLAMIDE / 4 h / 20 - 80 °C / Inert atmosphere

5.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

5.2: pH 8

With hydrogenchloride; N-Bromosuccinimide; triethylamine; lithium hexamethyldisilazane; [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water;