2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

Base Information

Chemical Name:2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride
CAS No.:114218-10-9
Molecular Formula:C₂₁H₂₁ClO₅
Molecular Weight:390.832
Hs Code.:

Synonyms:2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

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Technology Process of 2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

There total 9 articles about 2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

: 114218-08-5,114218-09-6
methyl 2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranoside

: 114218-10-9
2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

Guidance literature:: With hydrogenchloride; presaturated glacial acetic acid; In acetic acid; 1.) room temp., 2.) 0 deg C, 30 min.;
DOI:10.1016/S0040-4020(01)86822-8

Reference yield:

: 28070-06-6
benzyl-3,4-O-isopropylidene-β-D-erythro-pentoribopyranosid-2-ulose

: 114218-10-9
2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / lithium aluminium deuteride / tetrahydrofuran / 1.) 15 min., 0 deg C, 2.) 3 h. room temp.

3: 79 percent / tributyltin deuteride / toluene / 23 h / Heating

4: 80 percent / 80percent acetic acid / 24 h / Ambient temperature

5: 93 percent / hydrogen chloride / 36 h / Ambient temperature

6: 1.) 1percent hydrogen chloride / 1.) 15 min., 2.) 0 deg C, 1 h.

7: 83.5 percent / presaturated glacial acetic acid, dry hydrogen chloride / acetic acid / 1.) room temp., 2.) 0 deg C, 30 min.

With hydrogenchloride; lithium aluminium deuteride; presaturated glacial acetic acid; tributyltin deuteride; acetic acid; In tetrahydrofuran; acetic acid; toluene;
DOI:10.1016/S0040-4020(01)86822-8

Reference yield:

: 2-deoxy-2,2'-dideuterio-D-erythropentose

: 114218-10-9
2-deoxy-2,2'-dideuterio-3,5-di-O-p-toluoyl-D-erythro-pentofuranosyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1percent hydrogen chloride / 1.) 15 min., 2.) 0 deg C, 1 h.

2: 83.5 percent / presaturated glacial acetic acid, dry hydrogen chloride / acetic acid / 1.) room temp., 2.) 0 deg C, 30 min.

With hydrogenchloride; presaturated glacial acetic acid; In acetic acid;
DOI:10.1016/S0040-4020(01)86822-8