2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

Base Information

Chemical Name:2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine
CAS No.:132625-24-2
Molecular Formula:C₅₃H₅₁N₅O₁₀S
Molecular Weight:950.081
Hs Code.:

Synonyms:2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

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Chemical Property of 2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

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Technology Process of 2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

There total 7 articles about 2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 132625-24-2
2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / dimethylsulfoxide / 3.5 h / Ambient temperature

2: 1) NEt₃ / 1) 0 to 5 deg C, 15 min, 2) 0 to 5 deg C, 10 min

3: 72 percent / KOH, NaBH₄ / methanol; benzene / 28 h / Ambient temperature

4: 1) NEt₃, 2) KOH / 1) CH₂Cl₂, RT, 15 min, 2) KOH, MeOH, RT, 5 min

With pyridine; potassium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; dimethyl sulfoxide; benzene;
DOI:10.1039/P19920000469

Reference yield:

: 132625-21-9
2-N,5’-O-bis(4,4’-dimethoxytrityl)-gunaosine

: 132625-24-2
2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NEt₃ / 1) 0 to 5 deg C, 15 min, 2) 0 to 5 deg C, 10 min

2: 72 percent / KOH, NaBH₄ / methanol; benzene / 28 h / Ambient temperature

3: 1) NEt₃, 2) KOH / 1) CH₂Cl₂, RT, 15 min, 2) KOH, MeOH, RT, 5 min

With potassium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; benzene;
DOI:10.1039/P19920000469

Reference yield:

: 118-00-3
G

: 132625-24-2
2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / dimethylsulfoxide / 3.5 h / Ambient temperature

2: 1) NEt₃ / 1) 0 to 5 deg C, 15 min, 2) 0 to 5 deg C, 10 min

3: 72 percent / KOH, NaBH₄ / methanol; benzene / 28 h / Ambient temperature

4: 1) NEt₃, 2) KOH / 1) CH₂Cl₂, RT, 15 min, 2) KOH, MeOH, RT, 5 min

With pyridine; potassium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; dimethyl sulfoxide; benzene;
DOI:10.1039/P19920000469