9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

Base Information

Chemical Name:9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one
CAS No.:132625-23-1
Molecular Formula:C₅₂H₄₉N₅O₈
Molecular Weight:871.99
Hs Code.:

9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

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Chemical Property of 9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

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Technology Process of 9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

There total 5 articles about 9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 140679-71-6
2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester

: 132625-23-1
9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

Guidance literature:: With potassium hydroxide; sodium tetrahydroborate; In methanol; benzene; for 28h; Ambient temperature;
DOI:10.1039/P19920000469

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 132625-23-1
9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / pyridine / dimethylsulfoxide / 3.5 h / Ambient temperature

2: 1) NEt₃ / 1) 0 to 5 deg C, 15 min, 2) 0 to 5 deg C, 10 min

3: 72 percent / KOH, NaBH₄ / methanol; benzene / 28 h / Ambient temperature

With pyridine; potassium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; dimethyl sulfoxide; benzene;
DOI:10.1039/P19920000469

Reference yield:

: 132625-21-9
2-N,5’-O-bis(4,4’-dimethoxytrityl)-gunaosine

: 132625-23-1
9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NEt₃ / 1) 0 to 5 deg C, 15 min, 2) 0 to 5 deg C, 10 min

2: 72 percent / KOH, NaBH₄ / methanol; benzene / 28 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; benzene;
DOI:10.1039/P19920000469