2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

Base Information

Chemical Name:2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine
CAS No.:1247023-39-7
Molecular Formula:C₅₇H₆₂N₉O₁₀P
Molecular Weight:1064.15
Hs Code.:

2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

Synonyms:2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

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Chemical Property of 2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

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Technology Process of 2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

There total 6 articles about 2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1247023-37-5
2-N-acetyl-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1247023-39-7
2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

Guidance literature:: With 4,5-dicyano-1H-imidazole; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 112233-74-6
N²-acetyl-O⁶-(diphenylcarbamoyl)guanine

: 1247023-39-7
2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.5 h / 20 °C

1.2: 5.5 h / 60 °C

2.1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 1.5 h / 20 °C

3.1: pyridine / 12 h / 20 °C

4.1: 4,5-dicyano-1H-imidazole / acetonitrile / 3 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1247023-35-3
2-N-acetyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

: 1247023-39-7
2-N-acetyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytriphenyl)methyl-2'-O,4'-C-(N-methylaminomethylene)-6-O-diphenylcarbamoylguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 12 h / 20 °C

2: 4,5-dicyano-1H-imidazole / acetonitrile / 3 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; In acetonitrile;