2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

Base Information

Chemical Name:2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide
CAS No.:159021-71-3
Molecular Formula:C₂₇H₂₅N₃O₂Se
Molecular Weight:502.474
Hs Code.:

Synonyms:2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

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Chemical Property of 2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

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Technology Process of 2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

There total 13 articles about 2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-24-7
acetic anhydride

: 159021-70-2
2-(5,6-Dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

: 159021-71-3
2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

Guidance literature:: With pyridine; at 80 ℃; for 0.5h;
DOI:10.1021/jo00101a043

Reference yield:

: 239-43-0
indolo<1,2-c>quinazoline

: 159021-71-3
2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) AcOH / 1.) r.t., 10 min, 2.) r.t., 3.0 h

2: 97 percent / benzene / 12 h / Ambient temperature

3: 70 percent / acetonitrile; H₂O / 5 h / Heating

4: 80 percent / conc. aq. HCl / dioxane / 96 h / Heating

5: 96 percent / (COCl)2 / acetonitrile; dimethylformamide / 5 h / Ambient temperature

6: pyridine / acetonitrile / 3 h / Ambient temperature

7: 80 percent / NaBH₄ / methanol / 10 h / Heating

8: 90 percent / pyridine / 0.5 h / 80 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; acetic acid; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00101a043

Reference yield:

: 32566-01-1
2-(2-aminophenyl)-1H-indole

: 159021-71-3
2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-N-(2-phenylselanyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / H₂O / 1 h / 90 °C

2: 1.) AcOH / 1.) r.t., 10 min, 2.) r.t., 3.0 h

3: 97 percent / benzene / 12 h / Ambient temperature

4: 70 percent / acetonitrile; H₂O / 5 h / Heating

5: 80 percent / conc. aq. HCl / dioxane / 96 h / Heating

6: 96 percent / (COCl)2 / acetonitrile; dimethylformamide / 5 h / Ambient temperature

7: pyridine / acetonitrile / 3 h / Ambient temperature

8: 80 percent / NaBH₄ / methanol / 10 h / Heating

9: 90 percent / pyridine / 0.5 h / 80 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; acetic acid; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00101a043