tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate
CAS No.:1393901-46-6
Molecular Formula:C₂₁H₂₅ClF₃N₅O₂
Molecular Weight:471.91
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 304897-49-2
4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline

: 1393901-46-6
tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 0 ℃; for 1h;

4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline; With triethylamine; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; Cooling with ice;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1393901-46-6
tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

3.2: 20 °C / Cooling with ice

With hydrogen; sodium carbonate; zinc(II) chloride; palladium 10% on activated carbon; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 130636-61-2
1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine

: 1393901-46-6
tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

2.2: 20 °C / Cooling with ice

With hydrogen; zinc(II) chloride; palladium 10% on activated carbon; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;