N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

Base Information

Chemical Name:N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide
CAS No.:1616290-15-3
Molecular Formula:C₂₇H₃₂N₂O₅
Molecular Weight:464.561
Hs Code.:

Synonyms:N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

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Chemical Property of N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

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Technology Process of N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

There total 11 articles about N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1616288-89-1
2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

: 1616290-13-1
3-ethoxy-6-hydroxy-2-methylbenzoic acid

: 1616290-15-3
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

Guidance literature:: 3-ethoxy-6-hydroxy-2-methylbenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 3h;

2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol; In tetrahydrofuran; at 60 ℃; for 16h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616290-15-3
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: methanol / 1 h / 20 °C

4.1: methanol; sodium cyanoborohydride / 0 - 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 60 °C

5.2: 16 h / 60 °C

5.3: 1 h / 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 721959-71-3
2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

: 1616290-15-3
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 1 h / 20 °C

2.1: methanol; sodium cyanoborohydride / 0 - 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 60 °C

3.2: 16 h / 60 °C

3.3: 1 h / 20 °C

With methanol; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;