2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

Base Information

Chemical Name:2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide
CAS No.:1426095-62-6
Molecular Formula:C₂₅H₂₄FN₃O₂
Molecular Weight:417.483
Hs Code.:

Synonyms:2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

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Chemical Property of 2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

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Technology Process of 2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

There total 7 articles about 2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851985-81-4
7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline

: 1426096-49-2
N-(4-bromo-2-fluorophenyl)-2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-methylacetamide

: 1426095-62-6
2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h;

Reference yield:

: 580-20-1
quinolin-7-ol

: 1426095-62-6
2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1.58 h / 0 - 20 °C

2: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,4-dioxane; water;

Reference yield:

: 183062-96-6
2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid

: 1426095-62-6
2-[1-cyclopropylcarbonyl-3-azetidinyl]-N-[2-fluoro-4-(7-quinolinyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 0.17 h / 0 °C

1.2: 72 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

With 4-methyl-morpholine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloroformic acid ethyl ester; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;