1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide

Base Information

• Chemical Name: 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide
• CAS No.: 111087-12-8
• Molecular Formula: C₁₈H₂₁N₅O₆
• Molecular Weight: 403.395
• Mol file: 111087-12-8.mol

Synonyms:1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide

Chemical Property of 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide

There total 2 articles about 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(4-aminophenyl)-N'-methylurea (111087-13-9) + thymidine-5'-carboxylic acid (3544-99-8) → 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide (111087-12-8)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; for 6h; Ambient temperature;

DOI:10.1021/jm00396a039

Reference yield:

1,4-phenylenediamine (106-50-3) → 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide (111087-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / CHCl₃

2: 85 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 6 h / Ambient temperature

With diphenylphosphoranyl azide; triethylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm00396a039

Reference yield: 83.0%

1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide (111087-12-8) → 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methyl-3-nitrosoureido)phenyl>-β-D-ribofuranuronamide

Guidance literature:

With formic acid; sodium nitrite; at 0 ℃; for 1h;

DOI:10.1021/jm00396a039

upstream raw materials:

N-(4-aminophenyl)-N'-methylurea

thymidine-5'-carboxylic acid

1,4-phenylenediamine