morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide

Base Information

• Chemical Name: morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide
• CAS No.: 932036-94-7
• Molecular Formula: C₁₃H₁₃F₃N₂O₃
• Molecular Weight: 302.253
• Mol file: 932036-94-7.mol

Synonyms:morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide

Chemical Property of morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide

There total 3 articles about morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-morpholinocarbonyl chloride (15159-40-7) + 4-(trifluoroacetyl)aniline (23516-79-2) → morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide (932036-94-7)

Guidance literature:

With diethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

4-nitrobenzoic acid methyl ester (619-50-1) → morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide (932036-94-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TBAF / CH₂Cl₂ / -78 - 20 °C

1.2: 92 percent / aq. HCl / acetone

2.1: 79 percent / Fe; AcOH / ethanol / Heating

3.1: diethylamine / CH₂Cl₂ / 20 °C

With tetrabutyl ammonium fluoride; iron; acetic acid; diethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

α,α-bis(trifluoromethyl)-4-nitrobenzylalkohol (144459-68-7) → morpholine-4-carboxylic acid (4-trifluoroacetyl-phenyl)-amide (932036-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Fe; AcOH / ethanol / Heating

2: diethylamine / CH₂Cl₂ / 20 °C

With iron; acetic acid; diethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.09.023

upstream raw materials:

4-morpholinocarbonyl chloride

4-(trifluoroacetyl)aniline

4-nitrobenzoic acid methyl ester

α,α-bis(trifluoromethyl)-4-nitrobenzylalkohol