6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Base Information

Chemical Name:6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
CAS No.:1354742-77-0
Molecular Formula:C₁₅H₁₀FNO₃
Molecular Weight:271.248
Hs Code.:

Synonyms:6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

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Chemical Property of 6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

There total 7 articles about 6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₈FNO₄

: 1354742-77-0
6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: With toluene-4-sulfonic acid; In methanol; Inert atmosphere;
DOI:10.1016/j.bmc.2011.10.058

Reference yield:

: 1354742-59-8
2-(carboxymethyl)-4-iodobenzoic acid

: 1354742-77-0
6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: chlorobenzene / 130 °C / Inert atmosphere

2.2: 0.01 h / Reflux; Inert atmosphere

3.1: toluene-4-sulfonic acid / methanol / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; In methanol; ethanol; water; chlorobenzene; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.058

Reference yield:

: 99-60-5
2-chloro-4-nitrobenzoic acid

: 1354742-77-0
6-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate; copper(I) bromide / 100 °C / Inert atmosphere

1.2: pH 1

2.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

2.2: pH 1 / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 2250.23 Torr

4.1: sulfuric acid; sodium nitrite / water / -15 - 0 °C / Inert atmosphere

4.2: -10 - 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

6.1: chlorobenzene / 130 °C / Inert atmosphere

6.2: 0.01 h / Reflux; Inert atmosphere

7.1: toluene-4-sulfonic acid / methanol / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; toluene-4-sulfonic acid; copper(I) bromide; sodium hydroxide; sodium nitrite; In methanol; ethanol; water; chlorobenzene; 5.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.058