benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Base Information

• Chemical Name: benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
• CAS No.: 820239-44-9
• Molecular Formula: C₁₉H₂₀N₄O₃
• Molecular Weight: 352.393
• Mol file: 820239-44-9.mol

Synonyms:benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Chemical Property of benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

There total 1 articles about benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + (S)-N-(benzyloxycarbonyl)valine (1149-26-4) → benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (820239-44-9)

Guidance literature:

1,2,3-Benzotriazole; With thionyl chloride; In tetrahydrofuran; at 25 ℃; for 0.333333h;

(S)-N-(benzyloxycarbonyl)valine; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1055/s-2004-831255

Reference yield: 98.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (820239-44-9) → N-benzyloxycarbonyl-L-valyl-L-phenylalanine (19542-51-9)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃;

DOI:10.1055/s-2004-831255

Reference yield: 98.0%

2-amino-1-benzylbenzimidazole (43182-10-1) + benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (820239-44-9) → benzyl N-{(1S)-1-[(1-benzyl-1H-benzimidazol-2-yl)amino]carbonyl-2-methylpropyl}carbamate (1039552-94-7)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 0.5h; microwave irradiation;

DOI:10.1021/jo8007379

upstream raw materials:

1,2,3-Benzotriazole

(S)-N-(benzyloxycarbonyl)valine

Downstream raw materials:

N-benzyloxycarbonyl-L-valyl-L-phenylalanine

(2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoyl)amino]-3-(1H-indol-3-yl)propanoic acid

benzyl N-{(1S)-1-[(1-benzyl-1H-benzimidazol-2-yl)amino]carbonyl-2-methylpropyl}carbamate

(S)-benzyl (4-methyl-2-oxo-1-(pyridin-4-yl)pentan-3-yl)carbamate