Z-Val-phe-OH

Base Information

• Chemical Name: Z-Val-phe-OH
• CAS No.: 19542-51-9
• Molecular Formula: C22H26 N2 O5
• Molecular Weight: 398.459
• DSSTox Substance ID: DTXSID50941313
• Nikkaji Number: J440.273A
• Wikidata: Q82918106
• Mol file: 19542-51-9.mol

Synonyms:CBZ-VF-OMe;N-benzyloxycarbonyl-Val-Phe methyl ester;N-benzyloxycarbonyl-valyl-phenylalanine methyl ester;Z-Val-Phe methyl ester;Z-Val-Phe-OMe

Chemical Property of Z-Val-phe-OH

Chemical Property:

• Vapor Pressure: 1.04E-17mmHg at 25°C
• Melting Point: 150 °C
• Boiling Point: 648.6 °C at 760 mmHg
• PKA: 3.53±0.10(Predicted)
• Flash Point: 346.1 °C
• PSA: 104.73000
• Density: 1.211 g/cm³
• LogP: 3.53130
• Storage Temp.: −20°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 398.18417193
• Heavy Atom Count: 29
• Complexity: 539

Purity/Quality:

99% ^*data from raw suppliers

Z-Val-Phe-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)OCC2=CC=CC=C2
• Isomeric SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of Z-Val-phe-OH

There total 10 articles about Z-Val-phe-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + benzyl (S)-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (820239-44-9) → N-benzyloxycarbonyl-L-valyl-L-phenylalanine (19542-51-9)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃;

DOI:10.1055/s-2004-831255

Reference yield: 92.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + N-benzyloxycarbonyl-L-valine pentafluorophenyl ester (25529-25-3) → N-benzyloxycarbonyl-L-valyl-L-phenylalanine (19542-51-9)

Guidance literature:

With sodium 2,2,2-trifluoroacetate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 77.0%

N-Benzyloxycarbonyl-L-valyl-L-phenylalanin-allylester (88224-20-8) → N-benzyloxycarbonyl-L-valyl-L-phenylalanine (19542-51-9)

Guidance literature:

With Wilkinson's catalyst; In ethanol; water; at 70 ℃;

upstream raw materials:

2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate

L-phenylalanine

(S)-N-(benzyloxycarbonyl)valine

N-benzyloxycarbonyl-L-valine 2-pyridylthiol ester

Downstream raw materials:

(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

N-Z-valyl-L-phenylalanyl-L-glutamic acid γ-methylester

N-<(phenylmethoxy)carbonyl>-L-valyl-N'-methoxy-N'-methyl-L-phenylalaninamide

(N-Benzyloxycarbonyl-L-valyl-L-phenylalanyl)diazomethane

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