(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Base Information

Chemical Name:(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline
CAS No.:1380433-14-6
Molecular Formula:C₂₆H₂₀N₂O₃S₂
Molecular Weight:472.588
Hs Code.:

Synonyms:(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Suppliers and Price of (S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Chemical Property:

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Technology Process of (S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

There total 4 articles about (S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 36748-89-7
2-iodobenzothiophene

: 1380433-11-3
(S)-N-(2-phthalimidopropionyl)-2-methylthioaniline

: 1380433-14-6
(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Guidance literature:: With silver(I) acetate; palladium diacetate; In toluene; at 60 ℃; for 64h;
DOI:10.1002/anie.201200731

Reference yield:

: 4192-28-3
Phth-L-Ala-OH

: 1380433-14-6
(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / toluene / 2 h / 80 °C

2: 2,6-dimethylpyridine / dichloromethane / 20 °C

3: silver(I) acetate; palladium diacetate / toluene / 64 h / 60 °C

With 2,6-dimethylpyridine; silver(I) acetate; palladium diacetate; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1002/anie.201200731

Reference yield:

: 95-15-8,11095-43-5
Benzo[b]thiophene

: 1380433-14-6
(S)-N-(3-(benzothiophene-2-yl)-2-phthalimidopropionyl)-2-methylthioaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: silver(I) acetate; palladium diacetate / toluene / 64 h / 60 °C

With n-butyllithium; silver(I) acetate; palladium diacetate; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/anie.201200731