((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

Base Information

Chemical Name:((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone
CAS No.:200411-25-2
Molecular Formula:C₂₆H₃₃NO₃S
Molecular Weight:439.619
Hs Code.:

Synonyms:((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

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Chemical Property of ((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

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Technology Process of ((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

There total 9 articles about ((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: N-((E)-(R)-3-Benzenesulfonyl-1-butyl-nona-3,8-dienyl)-benzamide

: 200411-25-2
((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; for 12h; Ambient temperature;
DOI:10.1039/a706333d

Reference yield: 73.0%

: 200411-30-9
Acetic acid (R)-2-benzenesulfonyl-4-benzoylamino-1-pent-4-enyl-octyl ester

: 200411-25-2
((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; for 12h; Ambient temperature;
DOI:10.1039/a706333d

Reference yield:

: 80696-28-2,16397-19-6
(2R)-2-amino-2-butyl-1-ethanol

: 200411-25-2
((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NEt₃, 2.) NaH / 1.) THF, 0 deg C to r.t., 12 h, 2.) r.t., 1-2 weeks

2: BuLi / tetrahydrofuran; various solvent(s) / 1.) -78 deg C, 2.) -78 deg C to r.t., 12 h

3: BF₃*OEt₂ / methanol; CH₂Cl₂ / 12 h / Ambient temperature

4: pyridine / CH₂Cl₂ / 12 h / Ambient temperature

5: 1.) THF, Me₂N(CH₂)2NMe₂, -78 deg C, 40 min, 2.) -78 deg C to r.t., 12 h

6: 89 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.02 h / Ambient temperature

7: 79 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 12 h / Ambient temperature

With pyridine; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a706333d