3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

Base Information

• Chemical Name: 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• CAS No.: 171273-82-8
• Molecular Formula: C₁₈H₂₁ClN₂O₅S₃
• Molecular Weight: 477.026

Synonyms:3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

Chemical Property of 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

Chemical Property:

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Technology Process of 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

There total 2 articles about 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butylamine (75-64-9) + 2-(3-Methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide (171273-80-6) → 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (171273-82-8)

Guidance literature:

With N-chloro-succinimide; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

Reference yield:

tert-butylamine (75-64-9) + 3-chloromethyl-2-(3-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ6-thieno[3,2-e][1,2]thiazine-6-sulfonyl chloride → 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (171273-82-8)

Guidance literature:

In dichloromethane; for 16h;

DOI:10.1016/S0968-0896(00)00026-2

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + 3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (171273-82-8) → N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (286958-88-1)

Guidance literature:

3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide; With triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 1h;

morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1016/S0968-0896(00)00026-2

upstream raw materials:

tert-butylamine

2-(3-Methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide

Downstream raw materials:

N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

2-(3-hydroxy-phenyl)-1,1-dioxo-3-prop-2-ynylaminomethyl-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide

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