Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI)

Base Information

• Chemical Name: Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI)
• CAS No.: 389873-52-3
• Molecular Formula: C8H10 F2 O
• Molecular Weight: 160.1612064
• Mol file: 389873-52-3.mol

Synonyms:Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI)

Chemical Property of Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 1.41410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI)

There total 1 articles about Dispiro[2.0.2.1]heptane-1-methanol, 5,5-difluoro-, (1S,3R,4R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((1S,3R,4R)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-ylmethoxy)-tetrahydro-pyran → (1S,3R,4R)-6,6-difluorodispiro[2.0.2.1]hept-1-ylmethanol (389873-52-3) + ((1R,3S,4S)-5,5-Difluoro-dispiro[2.0.2.1]hept-1-yl)-methanol (321857-34-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; Heating;

DOI:10.1080/10587250108024994

Reference yield: 92.0%

(1S,3R,4R)-6,6-difluorodispiro[2.0.2.1]hept-1-ylmethanol (389873-52-3) + 2-(4-pentyl-1,1'-biphenyl-4'-yl)pyrimid-5-ol → (1S,3R,4R)-6,6-difluorodispiro[2.0.2.1]hept-1-ylmethyl 2-(4'-pentyl-1,1'-biphenyl-4-yl)pyrimid-5-yl ether

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1080/10587250108024994

Reference yield: 66.0%

(1S,3R,4R)-6,6-difluorodispiro[2.0.2.1]hept-1-ylmethanol (389873-52-3) + 4-(5-octylpyrimidin-2-yl)phenol (58415-63-7) → (1S,3R,4R)-6,6-difluorodispiro[2.0.2.1]hept-1-ylmethyl 4-(5-octylpyrimid-2-yl)phenyl ether

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1080/10587250108024994

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