3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester

Base Information

• Chemical Name: 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester
• CAS No.: 926010-03-9
• Molecular Formula: C₃₂H₃₃N₃O₅
• Molecular Weight: 539.631

Synonyms:3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester

Chemical Property of 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester

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Technology Process of 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester

There total 7 articles about 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-3-(4-methanesulfonyloxymethylphenyl)butyric acid methyl ester (926009-94-1) + 1-[2-methoxy-4-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-3-o-tolyl-urea → 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester (926010-03-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1016/j.bmcl.2006.08.044

Reference yield:

(R)-(-)-3-(4-hydroxymethylphenyl)butyric acid methyl ester (660440-47-1) → 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester (926010-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N / CH₂Cl₂

2: 87 percent / Cs₂CO₃ / dimethylformamide / 25 °C

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.08.044

Reference yield:

3-(4-hydroxymethyl-phenyl)-butyric acid (926009-93-0) → 3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester (926010-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / H₂SO₄ / Heating

2: 100 percent / Et₃N / CH₂Cl₂

3: 87 percent / Cs₂CO₃ / dimethylformamide / 25 °C

With sulfuric acid; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.08.044

upstream raw materials:

(R)-3-(4-methanesulfonyloxymethylphenyl)butyric acid methyl ester

(R)-(-)-3-(4-hydroxymethylphenyl)butyric acid methyl ester

3-(4-hydroxymethyl-phenyl)-butyric acid

3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide

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