4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Base Information

Chemical Name:4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide
CAS No.:203504-58-9
Molecular Formula:C₂₂H₂₈N₂O₄S
Molecular Weight:416.541
Hs Code.:

Synonyms:4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Suppliers and Price of 4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

There total 4 articles about 4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24093-81-0
methyl 3,5-dihydroxy-4-methoxybenzoate

: 203504-58-9
4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 3 h / Heating

2: 82 percent / diisobutylaluminum hydride / toluene; hexane / -78 °C / 15-20 min

3: 1.) lithium (bistrimethylsilyl)amide / 1.) THF, 2.) THF, -78 deg C

4: 1.) isopropyl alcohol / 1.) THF, toluene, room temperature, 15 min, 2.) THF, toluene, -78 deg C -> room temperature

With diisobutylaluminium hydride; potassium carbonate; isopropyl alcohol; lithium hexamethyldisilazane; In hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo972076s

Reference yield:

: 171738-30-0
methyl 3,5-diisopropoxy-4-methoxybenzoate

: 203504-58-9
4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / diisobutylaluminum hydride / toluene; hexane / -78 °C / 15-20 min

2: 1.) lithium (bistrimethylsilyl)amide / 1.) THF, 2.) THF, -78 deg C

3: 1.) isopropyl alcohol / 1.) THF, toluene, room temperature, 15 min, 2.) THF, toluene, -78 deg C -> room temperature

With diisobutylaluminium hydride; isopropyl alcohol; lithium hexamethyldisilazane; In hexane; toluene;
DOI:10.1021/jo972076s

Reference yield:

: 171738-31-1
4-methoxy-3,5-diisopropyloxybenzaldehyde

: 203504-58-9
4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium (bistrimethylsilyl)amide / 1.) THF, 2.) THF, -78 deg C

2: 1.) isopropyl alcohol / 1.) THF, toluene, room temperature, 15 min, 2.) THF, toluene, -78 deg C -> room temperature

With isopropyl alcohol; lithium hexamethyldisilazane;
DOI:10.1021/jo972076s