N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide

Base Information

• Chemical Name: N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide
• CAS No.: 179984-27-1
• Molecular Formula: C₂₅H₃₀INO₄S
• Molecular Weight: 567.488
• Mol file: 179984-27-1.mol

Synonyms:N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide

Chemical Property of N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide

There total 4 articles about N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1,6-hexanediol (629-11-8) + N-propargyl benzenesulfonamide (13630-91-6) + 1-(2-Chloromethyl-allyloxy)-2-iodo-benzene (179984-25-9) → N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide (179984-27-1)

Guidance literature:

1,6-hexanediol; 1-(2-Chloromethyl-allyloxy)-2-iodo-benzene; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

N-propargyl benzenesulfonamide; With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In benzene; at 0 - 20 ℃; for 24h;

DOI:10.1016/S0040-4020(00)00660-8

Reference yield:

N-propargyl benzenesulfonamide (13630-91-6) + 6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexan-1-ol → N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide (179984-27-1)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 25 ℃;

DOI:10.1016/0040-4039(96)00842-8

Reference yield:

1,6-hexanediol (629-11-8) → N-{6-[2-(2-Iodo-phenoxymethyl)-allyloxy]-hexyl}-N-prop-2-ynyl-benzenesulfonamide (179984-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 0 °C

2: ADDP, PBu₃ / toluene / 25 °C

With tributylphosphine; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/0040-4039(96)00842-8

upstream raw materials:

N-propargyl benzenesulfonamide

1,6-hexanediol

1-(2-Chloromethyl-allyloxy)-2-iodo-benzene