179984-25-9Relevant academic research and scientific papers
A Facile Construction of Bisheterocyclic Methane Scaffolds through Palladium-Catalyzed Domino Cyclization
Qi, Hongbo,Han, Kaiming,Chen, Shufeng
, p. 2699 - 2704 (2021)
A convenient palladium-catalyzed domino cyclization reaction for the construction of bis(benzofuranyl)methane scaffolds bearing an all-carbon quaternary center has been described. In the cascade process, one C(sp2)—O bond, two C(sp2)—C(sp3) bonds as well as two benzofuran rings are formed in a single synthetic sequence. The approach shows wide scope of substrates and good functional-group tolerance. Moreover, this methodology is successfully extended to the synthesis of benzofuranyl methyl chromane derivatives.
A Modular Approach for the Palladium-Catalyzed Synthesis of Bis-heterocyclic Spirocycles
Marchese, Austin D.,Durant, Andrew G.,Lautens, Mark
supporting information, p. 95 - 99 (2022/01/04)
A simple and modular approach toward bis-heterocyclic spirocycles using palladium catalysis is reported. The enclosed methodology leverages a Mizoroki–Heck-type reaction to generate a neopentylpalladium species. This species can undergo intramolecular C–H
Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes
He, Jun,Xue, Yuhang,Han, Bo,Zhang, Chunzhu,Wang, You,Zhu, Shaolin
supporting information, p. 2328 - 2332 (2020/01/08)
Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.
Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes
Tian, Zhi-Xiong,Qiao, Jin-Bao,Xu, Guang-Li,Pang, Xiaobo,Qi, Liangliang,Ma, Wei-Yuan,Zhao, Zhen-Zhen,Duan, Jicheng,Du, Yun-Fei,Su, Peifeng,Liu, Xue-Yuan,Shu, Xing-Zhong
supporting information, (2019/05/16)
Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, we report an enantioselective cross-el
Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes
Tian, Zhi-Xiong,Qiao, Jin-Bao,Xu, Guang-Li,Pang, Xiaobo,Qi, Liangliang,Ma, Wei-Yuan,Zhao, Zhen-Zhen,Duan, Jicheng,Du, Yun-Fei,Su, Peifeng,Liu, Xue-Yuan,Shu, Xing-Zhong
supporting information, p. 7637 - 7643 (2019/05/16)
Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, we report an enantioselective cross-el
Palladium-catalyzed carbohalogenation: Bromide to iodide exchange and domino processes
Newman, Stephen G.,Howell, Jennifer K.,Nicolaus, Norman,Lautens, Mark
supporting information; experimental part, p. 14916 - 14919 (2011/11/01)
Aryl bromides have been used to prepare a variety of nitrogen- and oxygen-containing heterocycles featuring new carbon-carbon and carbon-iodine bonds. This palladium-catalyzed carbohalogenation requires potassium iodide for the reaction to proceed in high yields. Additionally, the first examples of domino carbohalogenation reactions have been demonstrated using both aryl iodide and aryl bromide starting materials. Complex products with multiple rings and stereogenic centers are generated in excellent yields with moderate to excellent diastereoselectivities.
Synthesis of spiro- and fused heterocycles by palladium catalysed carbo- and heteroannulation cascades of allenes
Grigg,Koeppen,Rasparini,Sridharan
, p. 964 - 965 (2007/10/03)
Two novel palladium catalysed cascade processes involving the generation of a (π-allyl)palladium intermediate from allenes in an intra- or intermolecular fashion, followed by regioselective intramolecular nucleophilic addition of amines, alcohols or malon
