(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

Base Information

Chemical Name:(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine
CAS No.:1612891-41-4
Molecular Formula:C₁₉H₂₁F₃N₂O
Molecular Weight:350.384
Hs Code.:

Synonyms:(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

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Chemical Property of (2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

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Technology Process of (2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

There total 8 articles about (2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1612891-40-3
(5R,6R)-4-(4-methoxybenzyl)-5-phenyl-6-(trifluoromethyl)piperazin-2-one

: 1612891-41-4
(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-36-7
C₂₄H₂₅NO₃

: 1612891-41-4
(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

2: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 70 °C / Sealed tube; Inert atmosphere

4: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

5: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

6: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride; tetramethylammonium fluoride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; mineral oil;
DOI:10.1021/jo500832j

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1612891-41-4
(2R,3R)-1-(4-methoxybenzyl)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetonitrile / 60 h / 60 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.83 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; 1,4-dioxane / 70 °C / Sealed tube; Inert atmosphere

6.1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride; oxalyl dichloride; tetramethylammonium fluoride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500832j