(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

Base Information

Chemical Name:(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester
CAS No.:1449418-57-8
Molecular Formula:C₁₉H₂₄O₇
Molecular Weight:364.395
Hs Code.:

Synonyms:(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

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Chemical Property of (R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

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Technology Process of (R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

There total 1 articles about (R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 151864-81-2
ethyl 4-(3-oxopropyl)benzoate

: 105-53-3
diethyl malonate

: 1449418-57-8
(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; oxygen; palladium diacetate; In dimethyl sulfoxide; at 20 ℃; for 32h; enantioselective reaction;
DOI:10.1039/c3cc44214d

Reference yield:

: 1449418-57-8
(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

: C₁₉H₂₄O₈

Guidance literature:: With potassium permanganate; disodium hydrogenphosphate; In water; tert-butyl alcohol; for 0.0833333h;
DOI:10.1039/c3cc44214d

Reference yield:

: 1449418-57-8
(R)-2-(3-oxo-1-(4-ethoxycarbonylphenyl)propyl)malonic acid diethyl ester

: 1449418-71-6
(R)-2-ethoxycarbonyl-3-(4-ethoxycarbonylphenyl)pentane-1,5-dioic acid 1-ethyl ester 5-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate; disodium hydrogenphosphate / tert-butyl alcohol; water / 0.08 h

2: thionyl chloride / 0 - 20 °C

With potassium permanganate; disodium hydrogenphosphate; thionyl chloride; In water; tert-butyl alcohol;
DOI:10.1039/c3cc44214d