3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)

Base Information

Chemical Name:3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)
CAS No.:301651-23-0
Molecular Formula:C₁₁H₂₁NO₃
Molecular Weight:215.293
Hs Code.:
Mol file:301651-23-0.mol

Synonyms:3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)

Suppliers and Price of 3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)

Chemical Property:

Boiling Point:281.2±50.0 °C(Predicted)
PKA:3.75±0.40(Predicted)
Density:1.07±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI)

There total 4 articles about 3a(4H)-Benzofuranamine,2-ethoxyhexahydro-N-methoxy-,(2R,3aS,7aR)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 301651-22-9
2-(1-ethoxy-2-iodo-ethoxy)-cyclohexanone O-methyl-oxime

: 301651-23-0,301651-24-1
N-(2-ethoxy-hexahydro-benzofuran-3a-yl)-O-methyl-hydroxylamine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3.5h; Heating;
DOI:10.1021/jo000325y

Reference yield:

: 2-(2-bromo-1-ethoxy-ethoxy)-cyclohexanone O-methyl-oxime

: 301651-23-0,301651-24-1
N-(2-ethoxy-hexahydro-benzofuran-3a-yl)-O-methyl-hydroxylamine

Guidance literature:: With (pyridine)Co(dimethylglyoxime)2Cl; tetraethylammonium tosylate; In methanol; at 20 ℃; Electrolysis;
DOI:10.1055/s-2001-11412

Reference yield:

: 60308-50-1,30282-14-5
2-hydroxycyclohexanone dimer

: 301651-23-0,301651-24-1
N-(2-ethoxy-hexahydro-benzofuran-3a-yl)-O-methyl-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 85 percent / NIS / tetrahydrofuran / -78 - 20 °C

3: 77 percent / n-Bu₃SnH; AIBN / benzene / 3.5 h / Heating

With N-iodo-succinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 1: Condensation / 2: Addition / 3: Cyclization;
DOI:10.1021/jo000325y