N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine

Base Information

• Chemical Name: N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine
• CAS No.: 727720-12-9
• Molecular Formula: C₂₄H₃₂N₂O₃
• Molecular Weight: 396.53
• Mol file: 727720-12-9.mol

Synonyms:N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine

Chemical Property of N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine

There total 3 articles about N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

phenylacetic acid (103-82-2) + 4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine (337340-02-0) → N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine (727720-12-9)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm031080v

Reference yield:

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione (94142-97-9) → N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine (727720-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ethanol / 12 h / 20 °C

2: 61 percent / HOBt; DIEA; DCC / CH₂Cl₂ / 18 h / 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm031080v

Reference yield:

4-Aminomethylpiperidine (7144-05-0) → N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine (727720-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ethanol / 12 h / 20 °C

2: 61 percent / HOBt; DIEA; DCC / CH₂Cl₂ / 18 h / 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm031080v

upstream raw materials:

phenylacetic acid

4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione

4-Aminomethylpiperidine

Downstream raw materials:

N-(phenylacetyl)-4-[(6-(tert-butoxycarbonylamino)hexanoylamidomethyl)]piperidine

N-phenylacetyl-4-aminomethylpiperidine