2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-

Base Information

Chemical Name:2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-
CAS No.:133747-98-5
Molecular Formula:C₁₂H₁₅NO₃
Molecular Weight:221.256
Hs Code.:
DSSTox Substance ID:DTXSID401213319

Synonyms:133747-98-5;2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-;4-(hydroxymethyl)-1-(4-methoxyphenyl)pyrrolidin-2-one;SCHEMBL6269927;DTXSID401213319;AKOS013530212;4-(Hydroxymethyl)-1-(4-methoxyphenyl)-2-pyrrolidinone;F2147-1807

Suppliers and Price of 2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:221.10519334
Heavy Atom Count:16
Complexity:249

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2CC(CC2=O)CO

Technology Process of 2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)-

There total 11 articles about 2-Pyrrolidinone, 4-(hydroxymethyl)-1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 133747-97-4
methyl 1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxylate

: 133747-98-5
1-(4-methoxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; Heating;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: C₁₄H₁₇NO₄

: 133747-98-5
1-(4-methoxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 10 - 25 ℃; for 3.5h;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 56617-47-1
1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid

: 133747-98-5
1-(4-methoxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: Multi-step reaction with 2 steps

1: 89.3 percent / conc. H₂SO₄ / CH₂Cl₂ / 14 h / Heating

2: 98.8 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

With methanol; sodium tetrahydroborate; sulfuric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0223-5234(94)90029-9