Technology Process of (E)-1-(furan-2-yl)-5-phenylpent-1-en-3-ol
There total 4 articles about (E)-1-(furan-2-yl)-5-phenylpent-1-en-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
phenyllithium; lithium bromide;
In
tetrahydrofuran; dibutyl ether;
at -78 - 20 ℃;
for 0.166667h;
Inert atmosphere;
With
phenyllithium;
In
tetrahydrofuran; dibutyl ether;
at -78 - 20 ℃;
for 0.5h;
Inert atmosphere;
furfural; 3-phenyl-propionaldehyde;
regioselective reaction; Further stages;
DOI:10.1039/c2ob26346g
- Guidance literature:
-
With
chromium dichloride; zirconocene dichloride; (1,2-dimethoxyethane)dichloronickel(II); 2,9-di-n-butyl-1,10-phenanthroline; tetrabutylammomium bromide;
In
N,N-dimethyl-formamide;
Inert atmosphere;
Electrochemical reaction;
DOI:10.1021/jacs.1c03007
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine / dichloromethane / 0 - 20 °C
2.1: Dimethyl phosphite; triethylamine / 0 - 20 °C / Inert atmosphere; Sealed tube
2.2: 1.5 h / Reflux
3.1: tetrabutylammomium bromide; chromium dichloride; (1,2-dimethoxyethane)dichloronickel(II); zirconocene dichloride; 2,9-di-n-butyl-1,10-phenanthroline / N,N-dimethyl-formamide / Inert atmosphere; Electrochemical reaction
With
chromium dichloride; zirconocene dichloride; (1,2-dimethoxyethane)dichloronickel(II); 2,9-di-n-butyl-1,10-phenanthroline; tetrabutylammomium bromide; triethylamine; Dimethyl phosphite; triphenylphosphine;
In
dichloromethane; N,N-dimethyl-formamide;
3.1: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1021/jacs.1c03007
