3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Base Information

Chemical Name:3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde
CAS No.:1428940-06-0
Molecular Formula:C₁₆H₁₀ClF₃N₂O
Molecular Weight:338.716
Hs Code.:

Synonyms:3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

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Chemical Property of 3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Chemical Property:

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Technology Process of 3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

There total 4 articles about 3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3-bromo-1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

: 1312704-84-9
1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde

: 1548128-56-8
C₁₆H₁₂ClF₃N₂O

: 1548128-59-1
C₁₆H₁₁F₃N₂O

: 1428940-06-0
3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Guidance literature:: With 5%-palladium/activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; ethyl acetate; at 20 ℃; for 3h; under 258.581 Torr; Inert atmosphere;
DOI:10.1021/op400325r

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 886496-75-9
1-(bromomethyl)-4-chloro-2-(trifluoromethyl)benzene

: 1312704-84-9
1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde

: 1428940-06-0
3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 16h;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 1312704-84-9
1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazole-5-carbaldehyde

: 1548128-56-8
C₁₆H₁₂ClF₃N₂O

: 1428940-06-0
3-bromo-2-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile / 4.08 h / 20 - 34.9 °C

2: N,N-dimethyl-formamide / 0.87 h / 20 - 37.8 °C

3: hydrogen; water; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon / ethyl acetate; ethanol / 3 h / 20 °C / 258.58 Torr / Inert atmosphere

With N-Bromosuccinimide; 5%-palladium/activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/op400325r