1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Base Information

Chemical Name:1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea
CAS No.:1381761-82-5
Molecular Formula:C₃₀H₄₄N₈O₄
Molecular Weight:580.731
Hs Code.:

1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Synonyms:1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

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Chemical Property of 1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

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Technology Process of 1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

There total 4 articles about 1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381761-81-4
(R)-1-(4-(tert-butyl)phenyl)-3-(1-oxopentan-3-yl)urea

: 34245-49-3
5'-deoxy-5'-methylamino-2',3'-O,O-(1-methylethylidene)adenosine

: 1381761-82-5
1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 15.5h;

Reference yield:

: 131347-76-7
(R)-β-aminopentanoic acid

: 1381761-82-5
1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 1 h / -10 °C

1.2: 15 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

2.2: 15 h / 20 °C

3.1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: 2-iodoxybenzoic acid / ethyl acetate / 1.5 h / Reflux; Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15.5 h / 20 °C

With lithium borohydride; thionyl chloride; 2-iodoxybenzoic acid; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1381761-79-0
(R)-methyl 3-(3-(4-(tert-butyl)phenyl)ureido)pentanoate

: 1381761-82-5
1-((R)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C

2: 2-iodoxybenzoic acid / ethyl acetate / 1.5 h / Reflux; Inert atmosphere

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15.5 h / 20 °C

With lithium borohydride; 2-iodoxybenzoic acid; sodium tris(acetoxy)borohydride; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane;