(+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide
• CAS No.: 1448804-67-8
• Molecular Formula: C₂₀H₂₃N₃O₆S
• Molecular Weight: 433.485
• Mol file: 1448804-67-8.mol

Synonyms:(+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide

Chemical Property of (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide

There total 5 articles about (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzenesulfonyl isocyanate (5769-16-4) + C13H19NO*ClH (1448804-58-7) → (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide (1448804-67-8)

Guidance literature:

C₁₃H₁₉NO*ClH; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-nitrobenzenesulfonyl isocyanate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja405394v

Reference yield:

p-nitrobenzenesulfonamide (6325-93-5) → (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide (1448804-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phenanthridine; bis(trichloromethyl) carbonate / 1,2-dichloro-benzene / 100 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With phenanthridine; bis(trichloromethyl) carbonate; triethylamine; In tetrahydrofuran; 1,2-dichloro-benzene;

DOI:10.1021/ja405394v

Reference yield:

C14H21NO2S → (+/-)-N-((1-(4-methoxyphenyl)-2-methylpent-4-en-2-yl)carbamoyl)-4-nitrobenzenesulfonamide (1448804-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 0 °C

2.1: hydrogenchloride / water; methanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/ja405394v

upstream raw materials:

4-nitrobenzenesulfonyl isocyanate

C₁₃H₁₉NO*ClH

p-nitrobenzenesulfonamide

4-methoxybenzyl methyl ketone