1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI)
• CAS No.: 389621-34-5
• Molecular Formula: C₁₀H₂₀N₂
• Molecular Weight: 168.282
• Mol file: 389621-34-5.mol

Synonyms:1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI)

Chemical Property of 1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI)

Chemical Property:

• PSA: 29.26000
• LogP: 1.70210

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI)

There total 6 articles about 1H-Pyrrolizin-1-amine,hexahydro-2-(1-methylethyl)-,(1R,2R,7aR)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(αR,3aS,8bS)-3,3-dimethyl-1-(α-phenylethyl)-1,3a,4,8b-tetrahydro-3H-isoxazolo[3,4-a]pyrrolizine (389621-24-3) → (1S,2S,7aS)-1-amino-2,3,5,6,7,7a-hexahydro-2-(1-methylethyl)-1H-pyrrolizine (389621-34-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 24h;

DOI:10.1016/S0040-4020(01)00785-2

Reference yield: 32.0%

(3aRS,8bRS)-1-benzyl-3,3-dimethyl-1,3a,4,8b-tetrahydro-3H-isoxazolo[3,4-a]pyrrolizine → (1RS,2RS,7aRS)-1-amino-2,3,5,6,7,7a-hexahydro-2-(1-methylethyl)-1H-pyrrolizine (389621-34-5) + (1RS,2RS,7aRS)-1-amino-2,3,5,6,7,7a-hexahydro-α,α-dimethyl-1H-2-pyrrolizinemethanol

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 24h;

DOI:10.1016/S0040-4020(01)00785-2

Reference yield:

1-(3-methyl-2-butenyl)-pyrrol-2-carbaldehyde (110719-45-4) → (1S,2S,7aS)-1-amino-2,3,5,6,7,7a-hexahydro-2-(1-methylethyl)-1H-pyrrolizine (389621-34-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 36 percent / MgSO₄ / diethyl ether / 144 h / 20 °C

2: 56 percent / toluene / 24 h / Heating

3: 66 percent / H₂; 0.06N HCl / 10 percent Pd(OH)2/C / methanol / 24 h

With hydrogenchloride; hydrogen; magnesium sulfate; palladium dihydroxide; In methanol; diethyl ether; toluene;

DOI:10.1016/S0040-4020(01)00785-2

upstream raw materials:

(αR,3aS,8bS)-3,3-dimethyl-1-(α-phenylethyl)-1,3a,4,8b-tetrahydro-3H-isoxazolo[3,4-a]pyrrolizine

1-(3-methyl-2-butenyl)-pyrrol-2-carbaldehyde

C₁₈H₂₂N₂O

C₁₇H₂₀N₂O