N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Chemical Name:N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide
CAS No.:700875-73-6
Molecular Formula:C₄₂H₄₆N₆O₁₁
Molecular Weight:810.861
Hs Code.:

N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Synonyms:N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Chemical Property of N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Technology Process of N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

There total 7 articles about N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 25152-20-9
5'-amino-5'-deoxythymidine

: {{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid; compound with triethyl-amine

: 700875-73-6
N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1081/NCN-120025243

Reference yield:

: 188779-49-9
N-(2-hydroxyethyl)-N-(thymin-1-yl-acetyl)glycine tert-butyl ester

: 700875-73-6
N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / pyridine / 4 h / 10 - 20 °C

2.1: aq. NaOH / dioxane / 3 h / 20 °C / pH 13

2.2: 67.3 percent / CHCl₃

3.1: 59 percent / TBTU; Et₃N / dimethylformamide / 2 h / 20 °C

With pyridine; sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120025243

Reference yield:

: 749906-73-8
{{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid tert-butyl ester

: 700875-73-6
N-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-N-({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaOH / dioxane / 3 h / 20 °C / pH 13

1.2: 67.3 percent / CHCl₃

2.1: 59 percent / TBTU; Et₃N / dimethylformamide / 2 h / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120025243