5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

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Chemical Name:5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt
CAS No.:635702-65-7
Molecular Formula:CH₄O₃S*C₂₁H₂₃N₇O₂S
Molecular Weight:533.632
Hs Code.:

Synonyms:5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

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Chemical Property of 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

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Technology Process of 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

There total 8 articles about 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 635702-64-6
pazopanib hydrochloride

: 75-75-2,98527-29-8
methanesulfonic acid

: 635702-65-7
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Guidance literature:: In water; for 0.0833333h; Heating / reflux;

Reference yield:

: 6494-19-5
3-methyl-6-nitro-1H-indazole

: 635702-65-7
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / dimethyl sulfoxide / 72 h / 50 °C

2.1: palladium 10% on activated carbon / methanol; water / 6 h / 25 - 30 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 4 - 7 h / 74 - 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 30 °C

5.1: methanol / 3 h / 20 °C / Heating / reflux

5.2: 4 h

6.1: water / 0.08 h / Heating / reflux

With sulfuric acid; sodium hydrogencarbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 635702-59-9
3-methyl-6-nitro-1H-indazole sulfate

: 635702-65-7
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane; dimethyl sulfoxide / 25 - 70 °C / Heating / reflux

2.1: palladium 10% on activated carbon / methanol; water / 6 h / 25 - 30 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 4 - 7 h / 74 - 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 - 30 °C

5.1: methanol / 3 h / 20 °C / Heating / reflux

5.2: 4 h

6.1: water / 0.08 h / Heating / reflux

With sodium hydrogencarbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;