(E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide

Base Information

• Chemical Name: (E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide
• CAS No.: 1403981-55-4
• Molecular Formula: C₂₄H₂₄N₂O₄S
• Molecular Weight: 436.532
• Mol file: 1403981-55-4.mol

Synonyms:(E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide

Chemical Property of (E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide

There total 1 articles about (E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(methyl)-N-(p-toluenesulfonyl)ethynylamine (1005500-75-3) + N-(4-methoxybenzylidene)aniline oxide (3585-93-1) → (E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide (1403981-55-4)

Guidance literature:

With platinum(II) chloride; In 1,2-dichloro-ethane; at 28 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol302621z

Reference yield:

(E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide (1403981-55-4) → C24H26N2O4S

Guidance literature:

With sodium cyanoborohydride; In tetrahydrofuran; at 28 ℃; for 0.333333h;

DOI:10.1021/ol302621z

Reference yield:

(E)-2-(2-(4-methoxybenzylideneamino)phenyl)-N-methyl-N-tosylacetamide (1403981-55-4) → 1-(4-methoxybenzyl)-1,3-dihydro-2H-indol-2-one (206064-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride / tetrahydrofuran / 0.33 h / 28 °C

2: siliaflash-G₆₀ / tetrahydrofuran / 1 h / 80 °C

With sodium cyanoborohydride; In tetrahydrofuran;

DOI:10.1021/ol302621z

upstream raw materials:

N-(methyl)-N-(p-toluenesulfonyl)ethynylamine

N-(4-methoxybenzylidene)aniline oxide

Downstream raw materials:

1-(4-methoxybenzyl)-1,3-dihydro-2H-indol-2-one