1005500-75-3

Basic information

• Product Name: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine
• Synonyms: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine
• CAS NO: 1005500-75-3
• Molecular Weight: 209.269
• Mol File: 1005500-75-3.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine(1005500-75-3)
• EPA Substance Registry System: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine(1005500-75-3)

Safety Data

• Hazardous Substances Data: 1005500-75-3(Hazardous Substances Data)

Usage

General Description

N-(methyl)-N-(p-toluenesulfonyl)ethynylamine is a chemical compound with the molecular formula C11H13NO2S. It is commonly used as a reagent in chemical reactions, specifically in the synthesis of various organic compounds. N-(methyl)-N-(p-toluenesulfonyl)ethynylamine is a derivative of ethynylamine, and its structure includes a methyl group and a p-toluenesulfonyl group attached to the nitrogen atom. N-(methyl)-N-(p-toluenesulfonyl)ethynylamine is known for its ability to react with a variety of substrates, making it a versatile tool in organic synthesis. Its reactivity and structure make it valuable in the development of pharmaceuticals, agrochemicals, and other fine chemicals.

Upstream product

• 79-00-5 1,1,2-trichloroethane 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 156-59-2 cis-1,2-Dichloroethylene 
• 98-59-9 p-toluenesulfonyl chloride 
• 75-35-4 1,1-Dichloroethylene 
• 1007597-63-8 N-(methyl)-N-(p-toluenesulfonyl)-2-(triisopropylsilyl)ethynylamine 
• 872349-00-3 N,4-dimethyl-N-((trimethylsilyl)ethynyl)benzenesulfonamide 

Downstream Products

• 1303612-04-5 C₁₀H₁₀INO₂S 
• 1303612-05-6 C₁₂H₁₂INO₃S 
• 1303612-11-4 C₁₇H₂₁NO₃SSi 
• 1268600-17-4 N-(methyl)-N-(p-toluenesulfonyl)-5-butyl-3-hydroxy-2-methylamine 
• 1005500-76-4 N-(methyl)-N-(p-toluenesulfonyl)-2-methylethynylamine 
• 599-62-2 N-methyl-N-phenyltoluenesulfonamide 

Relevant articles and documents

Regio- and Stereo-Selective Intermolecular Hydroamidation of Ynamides: An Approach to (Z)-Ethene-1,2-Diamides

An efficient intermolecular trans-selective β-hydroamidation of ynamides to furnish a series of (Z)-ethene-1,2-diamide derivatives with excellent regio- and stereo-selectivities is described. The trans-β-addition reactions have been illustrated for a wide range of substrates and proceeded under basic reaction conditions using readily available materials in the absence of a transition-metal catalyst. The synthetic approach to these novel (Z)-ethene-1,2-diamide derivatives paves the way for further exploration of their synthetic application.

Copper-Catalyzed Synthesis of Terminal vs. Fluorine-Substituted N-Allenamides via Addition of Diazo Compounds to Terminal Ynamides

A copper-mediated coupling reaction between ynamides and diazo-compounds to produce N-allenamides is reported for the first time. This method enables facile and rapid access to terminal N-allenamides by using commercially available TMS-diazomethane with w

Direct Synthesis of CF2H-Substituted 2-Amidofurans via Copper-Catalyzed Addition of Difluorinated Diazoacetone to Ynamides

The significance of molecules containing difluoromethyl groups is driven by their potential applications in pharmaceutical and agrochemical science. Methods for the incorporation of lightly fluorinated groups such as CF2H have been less well developed. He

Catalytic Asymmetric Hydroacyloxylation/Ring-Opening Reaction of Ynamides, Acids, and Aziridines

A highly enantioselective three-component reaction of ynamides with carboxylic acids and 2,2′-diester aziridines has been realized by using a chiral N,N′-dioxide/Ho(OTf)3 complex as a Lewis acid catalyst. The process includes the formation of an α-acyloxyenamide intermediate through the addition of carboxylic acids to ynamides and the following enantioselective nucleophilic addition to in-situ-generated azomethine ylides induced by the chiral catalyst. A range of amino acyloxyenamides are delivered in moderate to good yields with good ee values. In addition, a possible catalytic cycle with a transition model is proposed to elucidate the reaction mechanism.