methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

Base Information

Chemical Name:methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate
CAS No.:1352548-20-9
Molecular Formula:C₂₂H₂₃NO₅S
Molecular Weight:413.494
Hs Code.:

Synonyms:methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

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Chemical Property of methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

Chemical Property:

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Technology Process of methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

There total 6 articles about methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1352548-13-0
methyl 3-[5-(4-methyl-2-aminophenyl)-2-furyl]propionate

: 98-59-9
p-toluenesulfonyl chloride

: 1352548-20-9
methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 425645-31-4
5-(4-methyl-2-nitro-phenyl)-furan-2-carbaldehyde

: 1352548-20-9
methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine / ethanol / 0.08 h / Reflux

2.1: sodium tetrahydroborate / ethanol / 0.17 h / Reflux

2.2: pH 7 / Cooling

3.1: hydrogenchloride; water; acetic acid / 0.67 h / Reflux

3.2: 0.5 h / Reflux

3.3: 20 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C

5.1: hydrazine hydrate / ethanol / 2 h / Reflux

6.1: pyridine / 12 h / 0 - 20 °C

With piperidine; pyridine; hydrogenchloride; sodium tetrahydroborate; water; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 1266525-99-8
2,2-dimethyl-5-([5-(4-methyl-2-nitrophenyl)-2-furyl]methylene)-[1,3]dioxane-4,6-dione

: 1352548-20-9
methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 0.17 h / Reflux

1.2: pH 7 / Cooling

2.1: hydrogenchloride; water; acetic acid / 0.67 h / Reflux

2.2: 0.5 h / Reflux

2.3: 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C

4.1: hydrazine hydrate / ethanol / 2 h / Reflux

5.1: pyridine / 12 h / 0 - 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; water; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.114