5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

Base Information

Chemical Name:5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid
CAS No.:1352548-31-2
Molecular Formula:C₂₁H₂₁NO₅S
Molecular Weight:399.467
Hs Code.:

Synonyms:5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

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Chemical Property of 5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

Chemical Property:

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Technology Process of 5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

There total 6 articles about 5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1352548-20-9
methyl 3-[5-(4-methyl-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-2-furyl]propanoate

: 1352548-31-2
5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

Guidance literature:: With perchloric acid; water; acetic acid; Reflux;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 425645-31-4
5-(4-methyl-2-nitro-phenyl)-furan-2-carbaldehyde

: 1352548-31-2
5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine / ethanol / 0.08 h / Reflux

2.1: sodium tetrahydroborate / ethanol / 0.17 h / Reflux

2.2: pH 7 / Cooling

3.1: hydrogenchloride; water; acetic acid / 0.67 h / Reflux

3.2: 0.5 h / Reflux

3.3: 20 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C

5.1: hydrazine hydrate / ethanol / 2 h / Reflux

6.1: pyridine / 12 h / 0 - 20 °C

7.1: perchloric acid; water; acetic acid / Reflux

With piperidine; pyridine; hydrogenchloride; sodium tetrahydroborate; perchloric acid; water; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 1266525-99-8
2,2-dimethyl-5-([5-(4-methyl-2-nitrophenyl)-2-furyl]methylene)-[1,3]dioxane-4,6-dione

: 1352548-31-2
5-(6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / ethanol / 0.17 h / Reflux

1.2: pH 7 / Cooling

2.1: hydrogenchloride; water; acetic acid / 0.67 h / Reflux

2.2: 0.5 h / Reflux

2.3: 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C

4.1: hydrazine hydrate / ethanol / 2 h / Reflux

5.1: pyridine / 12 h / 0 - 20 °C

6.1: perchloric acid; water; acetic acid / Reflux

With pyridine; hydrogenchloride; sodium tetrahydroborate; perchloric acid; water; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.114