C₃₆H₆₀O₉SeSi₃

Base Information

• Chemical Name: C₃₆H₆₀O₉SeSi₃
• CAS No.: 930280-05-0
• Molecular Formula: C₃₆H₆₀O₉SeSi₃
• Molecular Weight: 800.083
• Mol file: 930280-05-0.mol

Synonyms:C₃₆H₆₀O₉SeSi₃

Chemical Property of C₃₆H₆₀O₉SeSi₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₆₀O₉SeSi₃

There total 8 articles about C₃₆H₆₀O₉SeSi₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H42O8Si2 (930280-02-7) → C36H60O9SeSi3 (930280-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / diisopropylethylamine / DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 2.08 h / -78 - -12 °C

2.2: tetrahydrofuran / 3.17 h / cooling

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol062947x

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → C36H60O9SeSi3 (930280-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / diisopropylethylamine / DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 2.08 h / -78 - -12 °C

2.2: tetrahydrofuran / 3.17 h / cooling

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol062947x

Reference yield:

C30H56O9Si3 (930280-04-9) + Phenylselenyl chloride (5707-04-0) → C36H60O9SeSi3 (930280-05-0)

Guidance literature:

C₃₀H₅₆O₉Si₃; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -12 ℃; for 2.08333h;

Phenylselenyl chloride; In tetrahydrofuran; for 3.16667h; Further stages.; cooling;

DOI:10.1021/ol062947x

upstream raw materials:

C₃₀H₅₆O₉Si₃

Phenylselenyl chloride

C₂₄H₄₂O₈Si₂

C₃₁H₄₂O₇Si

Downstream raw materials:

thiapsigargin

Refernces

• 1、 Andrews, Stephen P.,Ball, Matthew,Wierschem, Frank,Cleator, Ed,Oliver, Steven,Hoegenauer, Klemens,Simic, Oliver,Antonello, Alessandra,Huenger, Udo,Smith, Martin D.,Ley, Steven V.. "Total synthesis of five thapsigargins: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition". . p. 5688 - 5712. Retrieved 2008/02/13.