((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

Base Information

Chemical Name:((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester
CAS No.:903907-87-9
Molecular Formula:C₂₂H₃₂N₂O₇
Molecular Weight:436.505
Hs Code.:

Synonyms:((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

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Chemical Property of ((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

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Technology Process of ((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

There total 5 articles about ((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 903907-86-8
[(1R,2R,6S)-6-benzyloxycarbonylamino-4-(tert-butyldiphenylsilanyloxymethyl)-2-methoxymethoxy-cyclohex-3-enyl]carbamic acid tert-butyl ester

: 903907-87-9
((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo060633h

Reference yield:

: 903907-80-2
[(2S)-benzyloxycarbonylamino-4-(tert-butyldiphenylsilanyloxymethyl)-(1R)-hydroxymethyl-pent-4-enyl]carbamic acid tert-butyl ester

: 903907-87-9
((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.81 g / ZnBr₂ / tetrahydrofuran / 6 h / -70 - -30 °C

2: 98 percent / DIPEA / CH₂Cl₂ / 24 h / 20 °C

3: 98 percent / 2nd generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

4: 96 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; zinc dibromide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; 1: Grignard addition;
DOI:10.1021/jo060633h

Reference yield:

: 903907-79-9
tert-butyl (R)-4-((S)-11,11-dimethyl-7-methylene-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-sila dodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

: 903907-87-9
((1S,5R,6R)-6-tert-butyloxycarbonylamino-3-hydroxymethyl-5-methoxymethoxy-cyclohex-3-enyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / BiBr₃ / acetonitrile / 5 h / 20 °C

2: 1.81 g / ZnBr₂ / tetrahydrofuran / 6 h / -70 - -30 °C

3: 98 percent / DIPEA / CH₂Cl₂ / 24 h / 20 °C

4: 98 percent / 2nd generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

5: 96 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

With bismuth(III) bromide; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; zinc dibromide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; acetonitrile; 2: Grignard addition;
DOI:10.1021/jo060633h