(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

Chemical Name:(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester
CAS No.:903907-74-4
Molecular Formula:C₁₁H₁₈N₂O₄
Molecular Weight:242.275
Hs Code.:

Synonyms:(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Suppliers and Price of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property:

Boiling Point:468.3±45.0 °C(Predicted)
Density:1.23±0.1 g/cm3(Predicted)

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

There total 13 articles about (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 903907-90-4
(3R,4R,5S)-4-acetylamino-5-benzyloxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

: 903907-74-4
(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: With triethylsilane; triethylamine; palladium diacetate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo060633h

Reference yield: 50.0%

: 1333341-63-1
(3R,4R,5S)-ethyl 5-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-acetamido-3-hydroxycyclohex-1-enecarboxylate

: 903907-74-4
(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: With morpholine; In methanol; dichloromethane; at 20 - 50 ℃;
DOI:10.1002/anie.201103261

Reference yield:

: (3R,4R,5S)-4-Amino-5-benzyloxycarbonylamino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

: 903907-74-4
(3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 262 mg / Na₂CO₃ / ethanol

2: 92 percent / Et₃N; Et₃SiH / Pd(OAc)2 / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; sodium carbonate; triethylamine; palladium diacetate; In ethanol; dichloromethane;
DOI:10.1021/jo060633h