(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

Base Information

Chemical Name:(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate
CAS No.:1489278-72-9
Molecular Formula:C₃₀H₃₆N₂O₅S
Molecular Weight:536.692
Hs Code.:

Synonyms:(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

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Chemical Property of (S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

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Technology Process of (S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

There total 5 articles about (S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 1489278-60-5
(S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-formyl-5-methylthiazol-2-yl)ethylcarbamate

: 1489278-72-9
(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

Guidance literature:: ethyl 2-diethoxyphosphorylpropionate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

(S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-formyl-5-methylthiazol-2-yl)ethylcarbamate; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489290-63-2
C₂₅H₃₀N₂O₄S

: 1489278-72-9
(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

2.2: 4 h / 20 °C

With sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 1489278-72-9
(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

5.2: 4 h / 20 °C

With Lawessons reagent; dmap; lithium aluminium tetrahydride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.09.017