(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

Base Information

Chemical Name:(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline
CAS No.:1314094-18-2
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

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Chemical Property of (-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

Chemical Property:

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Technology Process of (-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

There total 10 articles about (-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1314094-16-0
(-)-(R)-6,8-bis-(4-methoxybenzyloxy)-1-ethenyl-2-trifluoroacetyl-3,4-dihydro-1H-isoquinoline

: 1314094-18-2
(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 16h;
DOI:10.1021/jo2009615

Reference yield:

: 1314093-89-4
C₂₆H₂₅F₃INO₅

: 1314094-18-2
(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.33 h / 30 °C

1.2: 48 h / Reflux

2.1: sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; hydrogen; nickel diacetate / ethanol / 18 h / 760.05 Torr

3.1: pyridine / 3 h / 0 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; C₆₂H₆₄O₂P₂ / N,N-dimethyl-formamide / 20 °C

5.1: sodium hydroxide / ethanol / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; C₆₂H₆₄O₂P₂; hydrogen; nickel diacetate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1021/jo2009615

Reference yield:

: 1314093-91-8
1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

: 1314094-18-2
(-)-(R)-6,8-bis(4-methoxybenzyloxy)-3,4-dihydro-1-ethenyl-1H-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; hydrogen; nickel diacetate / ethanol / 18 h / 760.05 Torr

2: pyridine / 3 h / 0 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; C₆₂H₆₄O₂P₂ / N,N-dimethyl-formamide / 20 °C

4: sodium hydroxide / ethanol / 16 h / 20 °C

With pyridine; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N,N,N,-tetramethylethylenediamine; C₆₂H₆₄O₂P₂; hydrogen; nickel diacetate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo2009615