4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole

Base Information

• Chemical Name: 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole
• CAS No.: 114362-56-0
• Molecular Formula: C₁₈H₁₆N₆
• Molecular Weight: 316.365
• Mol file: 114362-56-0.mol

Synonyms:4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole

Chemical Property of 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole

There total 2 articles about 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (114362-54-8) + p-toluidine (106-49-0,12221-03-3) → 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole (114362-56-0)

Guidance literature:

With acetic acid; In ethanol; for 6h; Ambient temperature;

DOI:10.1021/jo00255a003

Reference yield:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) → 4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole (114362-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / sodium azide / dimethylsulfoxide / 1 h / 60 °C

2: 96 percent / acetic acid / ethanol / 6 h / Ambient temperature

With sodium azide; acetic acid; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jo00255a003

Reference yield: 83.0%

4-<(N-p-tolylimino)methyl>-5-azido-3-methyl-1-phenyl-1H-pyrazole (114362-56-0) → 3-Methyl-1-phenyl-5-p-tolylamino-1H-pyrazole-4-carbonitrile (135587-37-0)

Guidance literature:

Heating;

DOI:10.1016/0040-4039(91)80835-T

upstream raw materials:

5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde

p-toluidine

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

Downstream raw materials:

3-Methyl-1-phenyl-5-p-tolylamino-1H-pyrazole-4-carbonitrile

4-<(N-p-tolylimino)methyl>-3-methyl-1-phenyl-5-<(triphenylphosphoranylidene)amino>-1H-pyrazole

3-methyl-1-phenyl-5-tolyl-6-thioxo-5,6-dihydro-1H-pyrazolo<3,4-d>pyrimidines

Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine