N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide

Base Information

• Chemical Name: N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide
• CAS No.: 167215-79-4
• Molecular Formula: C₅₂H₄₈N₂O₃S₂
• Molecular Weight: 813.097
• Mol file: 167215-79-4.mol

Synonyms:N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide

Chemical Property of N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide

There total 5 articles about N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[4-(carbomethoxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide (167215-78-3) → N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide (167215-79-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1016/0960-894X(96)00282-X

Reference yield:

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide (167215-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 1,2-dichloro-ethane

2: 100 percent / 1N NaOH / dioxane

With sodium hydroxide; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1016/0960-894X(96)00282-X

Reference yield:

4-(methoxycarbonyl)benzyl alcohol (6908-41-4,58590-49-1) → N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide (167215-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: ethyl acetate; 1,2-dichloro-ethane

3: sodium hydroxide / 1,4-dioxane; ethyl acetate

With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; 1,2-dichloro-ethane;

upstream raw materials:

N-[4-(carbomethoxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide

methyl 4-(((methylsulfonyl)oxy)methyl)benzoate

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide

4-(methoxycarbonyl)benzyl alcohol

Downstream raw materials:

N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethyl-thio)ethyl]glycinamide N-hydroxysuccinimide ester