N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Base Information

Chemical Name:N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide
CAS No.:188662-13-7
Molecular Formula:C₃₁H₃₁NO₅
Molecular Weight:497.591
Hs Code.:

Synonyms:N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Chemical Property:

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Technology Process of N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

There total 9 articles about N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 188662-05-7
<2-<3,5-bis(benzyloxy)phenyl>ethyl>amine

: 188662-00-2
3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester

: 188662-13-7
N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Guidance literature:: With triethylamine; In chloroform; N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/jm960449w

Reference yield:

: 2316-26-9
3,4-dimethoxycinnamic acid

: 188662-13-7
N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 2068.6 Torr / Ambient temperature

2: 56 percent / pyridine*HCl / 1.5 h / 180 - 200 °C

3: 95 percent / dicyclohexylcarbodiimide / dioxane / Ambient temperature

4: 85 percent / Et₃N / CHCl₃; dimethylformamide / 2 h / Ambient temperature

With hydrogen; pyridine hydrochloride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960449w

Reference yield:

: 14615-72-6
3,5-dibenzyloxybenzaldehyde

: 188662-13-7
N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / ammonium acetate, gl. AcOH / 5 h / Heating

2: 28 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 2 h / Ambient temperature

3: 85 percent / Et₃N / CHCl₃; dimethylformamide / 2 h / Ambient temperature

With ammonium acetate; lithium aluminium tetrahydride; acetic acid; triethylamine; In diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960449w