17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

Base Information

Chemical Name:17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one
CAS No.:345901-68-0
Molecular Formula:C₂₉H₃₉NO₄
Molecular Weight:465.633
Hs Code.:

Synonyms:17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

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Chemical Property of 17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

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Technology Process of 17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

There total 3 articles about 17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 345901-68-0
17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

Guidance literature:

Reference yield: 88.73%

: 1094602-03-5
11β-[4-(dimethylamino)-phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[(trimethyl-silyl)-oxy]-5α-oestr-9-en-17β-carbaldehyde

: 107-30-2
chloromethyl methyl ether

: 345901-68-0
17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

Guidance literature:: chloromethyl methyl ether; With magnesium; ethylene dibromide; mercury dichloride; In tetrahydrofuran; toluene; at -5 - 40 ℃; Industry scale; Inert atmosphere;

11β-[4-(dimethylamino)-phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[(trimethyl-silyl)-oxy]-5α-oestr-9-en-17β-carbaldehyde; In tetrahydrofuran; toluene; at -5 - 0 ℃; for 1h; Industry scale; Inert atmosphere;

With potassium hydrogensulfate; In tetrahydrofuran; water; toluene; at 20 - 30 ℃; Product distribution / selectivity;

Reference yield: 72.3%

: 13057-17-5
bromethyl methyl ether

: 1094602-03-5
11β-[4-(dimethylamino)-phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[(trimethyl-silyl)-oxy]-5α-oestr-9-en-17β-carbaldehyde

: 345901-68-0
17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

Guidance literature:: bromethyl methyl ether; With magnesium; ethylene dibromide; mercury dichloride; In tetrahydrofuran; toluene; at 10 - 35 ℃; Inert atmosphere;

11β-[4-(dimethylamino)-phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[(trimethyl-silyl)-oxy]-5α-oestr-9-en-17β-carbaldehyde; In tetrahydrofuran; toluene; at 10 - 15 ℃; for 1h; Inert atmosphere;

With potassium hydrogensulfate; In tetrahydrofuran; water; toluene; at 20 - 30 ℃;