Telapristone

Base Information

• Chemical Name: Telapristone
• CAS No.: 198414-30-1
• Molecular Formula: C₂₉H₃₇NO₄
• Molecular Weight: 463.617
• Mol file: 198414-30-1.mol

Synonyms:Telapristone

Chemical Property of Telapristone

Chemical Property:

Purity/Quality:

>98% ^*data from raw suppliers

TELAPRISTONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Telapristone

There total 3 articles about Telapristone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile (91934-94-0) + chloromethyl methyl ether (107-30-2) → Telapristone (198414-30-1)

Guidance literature:

chloromethyl methyl ether; With biphenyl; lithium; In tetrahydrofuran; toluene; at -55 - -40 ℃; Inert atmosphere;

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; In tetrahydrofuran; toluene; at -55 - -50 ℃; for 3h;

With sulfuric acid; water; In tetrahydrofuran; toluene; at 20 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield: 94.44%

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile (1094602-02-4) + chloromethyl methyl ether (107-30-2) → Telapristone (198414-30-1)

Guidance literature:

chloromethyl methyl ether; With biphenyl; lithium; In tetrahydrofuran; toluene; at -55 - -40 ℃; for 0.333333h; Inert atmosphere;

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; In tetrahydrofuran; toluene; at -55 - -48 ℃; for 2.17h;

With sodium hydrogen sulfate; water; In tetrahydrofuran; toluene; at 15 - 20 ℃; Reagent/catalyst; Temperature;

Reference yield: 80.0%

17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one (345901-68-0) → Telapristone (198414-30-1)

Guidance literature:

With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In toluene; at 20 - 40 ℃; for 3h; Product distribution / selectivity; Inert atmosphere; Industry scale;

upstream raw materials:

17α,20-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

chloromethyl methyl ether

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

Downstream raw materials:

Telapristone acetate

Refernces

• 1、 -. "INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS". Page/Page column 12. . Retrieved 2010/06/16.