[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Base Information

Chemical Name:[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate
CAS No.:1439366-97-8
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

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Chemical Property of [4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

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Technology Process of [4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

There total 5 articles about [4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1439368-20-3
(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

: 1439366-97-8
[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm501455s

Reference yield:

: 13485-84-2
[4-(cyclohexyloxy)phenyl]methanol

: 1439366-97-8
[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

1.2: 15 h / 20 °C

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane;

Reference yield:

: ethyl 4-(cyclohexyloxy)benzoate

: 1439366-97-8
[4-(cyclohexoxy)-phenyl]methyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane;